3.業績 Publication

T.査読付英語原著論文

  [2015]

1.    , S. Sekiya, K. Nagoshi, S. Iwamoto, and K. Tanaka, M. Takayama,Timeframe Dependent Fragment Ions observed in In-Source Decay Experiments withb-Casein using MALDI MS, J. Am. Soc. Mass Spectrom., 26, 1588-1598 (2015). DOI: 10.1007/s13361-015-1173-3.

2.    N. Sugasawa, T. Kawase, M. Oshikata, R. Iimuro, A. Motoyama, M. Takayama, Formation of c- and z-ions due to preferential cleavage at the N-C bond of Xxx-Asp/Asn residues in negative-ion CID of peptides, Int. J. Mass Spectrom., 383-384, 38-43 (2015).

3.    K. Sekimoto, R. Gonda, M. Takayama, Effects of H3O+, OH-, O2-, NOx- and NOx for Escherichia coli inactivation in atmospheric pressure DC corona discharges, J. Phys. D., 48, 305401 (9pp) (2015).


[2014]

1.    S. Horiyama, Y. Takahashi,C. Honda, K. Suwa, A. Ichikawa,M. Hatai, N. Yoshikawa, K. Nakamura, M. Kunitomo, S. Date, T. Masujima and Mitsuo Takayama, Methyl Vinyl Ketone, a Toxic Ingredient in Cigarette Smoke Extract, Modifies Glutathione in Mouse Melanoma Cells,Chem. Pharm. Bull., 62, 772-778 (2014).

2.    K. Sekimoto, N. Matsuda and M Takayama, Formation of benzyl carbanion in collision-induced dissociation of deprotonatedphenylalanine homologues, Mass Spectrom. (Tokyo),2014; DOI:10.5702/massspectrometry.A0027.

3.    I. Osaka and M. Takayama, Influence of hydrophobicity on positive- and negative-ion yields of peptides in ESI-MS, Rapid Commun. Mass Spectrom., 28, 2222-2226 (2014).

4.    M. Takayama, K. Nagoshi, R. Iimuro and K. Inatomi, Access of Hydrogen-Radicals to the Peptide-Backbone as a Measure for estimating the Flexibility of Proteins using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Int. J. Mol. Sci., 15, 8428-8442 (2014); DOI:10.3390/ijms15058428.

5.    K. Sekimoto, M. Sakakura, T. Kawamukai, H. Hike, T. Shiota, F. Usui, Y. Bando and M. Takayama, Ionization characteristics of amino acids in direct analysis in real time mass spectrometry, Analyst, 139, 2589-2599 (2014).

6.    R. Iimuro and M. Takayama, Analysis of flexibility of proteins by means of positive and negative ion MALDI in-source decay mass spectrometry, Mass Spectrom. (Tokyo), 2014; DOI:10.5702/massspectrometry.S0023.

7.    M. Takayama, S.Sekiya, R. Iimuro, S. Iwamoto, and K. Tanaka, Selective and Nonselective Cleavages in Positive and Negative CID of the Fragments generated from In-Source Decay of Intact Proteins in MALDI-MS, J. Am. Soc. Mass Spectrom., 25, 120-131 (2014).

 

[2013]

1. D. Asakawa, M. Sakakura, and M. Takayama, Influence of Initial Velocity of Analytes on In-source Decay Products in MALDI Mass Spectrometry using Salicylic Acid Derivative Matrices, Int. J. Mass Spectrom., 337, 29-33 (2013)..

2. K. Sekimoto, N. Matsuda, M. Takayama, Collision-induced dissociation study of the adduct ions produced in NO3--free area of atmospheric pressure negative corona discharges under ambient air conditions, Mass Spectrom.(Tokyo), DOI:10.5702/massspectrometry.A0020. (2013).

3. K. Sekimoto and M. Takayama,Collision-induced dissociation analysis of negative atmospheric ion adducts in atmospheric pressure corona discharge ionization mass spectrometry, J. Am. Soc. Mass Spectrom., 24, 780-788 (2013). DOI:10.1007/s13361-013-0576-2.

4. Y. Nabuchi, K.Hirose and M.Takayama,Study of pH dependence of product ion spectra obtained from precursor ions with same charge number in ESI of carbonic anhydrase 2, Mass Spectrom.(Tokyo), DOI: 10.5702/massspectrometry.A0016, 2013.

5. I. Osaka, M. Sakai and M. Takayama, 5-Amino-1-naphthol, a novel 1,5-naphthalene derivative matrix suitable for MALDI in-source decay of phosphorylated peptides, Rapid Commun. Mass Spectrom., 27, 103-108 (2013).

6. Y. Takahashi, S. Horiyama, C. Honda, K. Suwa, K. Nakamura, M. Kunitomo, S. Shimma, M. Toyoda, H. Sato, M. Shizuma and M. Takayama, A chemical approach to searching for bioactive ingredients in cigarette smoke, Chem. Pharm. Bull., 61, 85-89 (2013).

 

[2012]

1. M. Takayama, Flexible Xxx-Asp/Asn and Gly-Xxx Residues and Formation of c’-/z.-ion Pair of Equine Cytochrome c in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mass Spectrometry, Mass Spectrom. (Tokyo). 2012; 1(2):A0007. DOI:10.5702/massspectrometry.A0007.

2. K.Sekimoto and M.Takayama, Surface analysis of traces stained with discharge on plane electrode in atmospheric pressure negative corona, Journal of Electrostatics, 70, 363-373 (2012).

3. Y.Nabuchi, K.Hirose and M.Takayama, Influence of Charge State of Precursor Ions on Collision-induced Dissociation of Carbonic Anhydrase 2, J. Mass Spectrom. Soc. Jpn, 60, 47-50 (2012).

4. D.Asakawa, M.Sakakura and M.Takayama, Matrix Effect on In-source Decay Products of Peptides in Matrix-assisted Laser Desorption/Ionization, Mass Spectrom (Tokyo). 2012; 1(2):A0002. DOI: 10.5702/massspectrometry.A0002.

5. M.Takayama, I.Osaka and M.Sakakura, Influence of Secondary Structure on In-source Decay of Protein in Matrix-assisted Laser Desorption/Ionization Mass Spectrometry, Mass Spectrom. (Tokyo), DOI: 10.5702/massspectrometry.A0001, 2012.

6. K.Sekimoto, M.Sakai and M.Takayama, Specific interaction between negative atmospheric ions and organic compounds in atmospheric pressure corona discharge ionization mass spectrometry, J. Am. Soc. Mass Spectrom., 23, 1109-1119 (2012).

7. D.Asakawa and M.Takayama, Fragmentation Processes of hydrogen-Deficient Peptide Radicals in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mass Spectrometry, J. Phys. Chem. B, 116, 4016-4023 (2012).

8. D.Asakawa and M.Takayama, Mass spectrometric characterization of phosphorylated peptides using MALDI in-source decay via redox reactions, J. Mass Spectrom., 47, 180-187 (2012).

9. M.Sakakura and M.Takayama, Improved sonolytic hydrolysis of peptides in aqueous solution with addition of 1,4-benzenedithiol, Ultrasonics Sonochemistry, 19, 615-620 (2012).

10. D.Asakawa, S.Moriguchi and M.Takayama, Influence of amino acid composition and phosphorylation on the ion yields of peptides in MALDI-MS, J. Am. Soc. Mass Spectrom., 23, 108-115 (2012).

 

[2011]

1. D.Asakawa and M.Takayama, Cα?C bond cleavage of the peptide backbone in MALDI in-source decay using salicylic acid derivative matrices, J. Am. Soc. Mass Spectrom., 22, 1224-1233 (2011).

2. K.Sekimoto and M.Takayama, Observation of different core water cluster ions Y-(H2O)n (Y=O2, HOx, NOx, COx) and magic number in atmospheric pressure corona discharge mass spectrometry, J. Mass Spectrom., 46, 50-60 (2011).

3. D.Asakawa and M.Takayama, Specific cleavage at peptide backbone Cα?Cand CO?N bonds during MALDI-ISD mass spectrometry with 5-nitrosalicylic acid as the matrix, Rapid Commun. Mass Spectrom., 25, 2379-2383 (2011).

4. K.Sekimoto and M.Takayama, Temperature dependence of magic number and first hydrated shell of various core water cluster ions Y-(H2O)n (Y= O2, HOx, NOx, COx) in atmospheric pressure negative corona discharge mass spectrometry, Int. J. Mass Spectrom., 306, 44-50  (2011).

 

[2010]

1. K.Sekimoto and M.Takayama, Negative ion formation and evolution in atmospheric pressure corona discharge between point-to-plane electrodes with arbitrary needle angle, European Physical Journal D, 60, 589-599 (2010).

2. Y.Nabuchi, K.Hirose and M.Takayama, Ion mobility and collision-induced dissociation analysis of carbonic anhydrase 2, Anal. Chem., 82, 8890-8896 (2010).

3. T.Nishikaze and M.Takayama, Influence of charge state and amino acid composition on hydrogen transfer in electron capture dissociation of peptides, J. Am. Soc. Mass Spectrom., 21, 1979-1988 (2010).

4. M.Sakakura and M.Takayama, In-source decay and fragmentation characteristics of peptides using 5-aminosalicylic acid as a matrix in matrix-assisted laser desorption/ionization mass spectrometry Journal of the American Society for Mass Spectrometry, J. Am. Soc. Mass Spectrom., 21, 979-988 (2010).

5. S.Horiyama, C.Honda, K.Suwa, Y.Okada, M.Semma, A.Ichikawa and M.Takayama, Negative and Positive Ion Mode LC/MS/MS for Simple, Sensitive Analysis of Sorbic Acid, Chem. Pharm. Bull., 58, 106-109 (2010).

6. H.Ichiba, M.Nakamoto, T.Yajima, M.Takayama and T. Fukushima, Analysis of oxidation process of cholecystokinin octapeptide with reactive oxygen species by high-performance liquid chromatography and subsequent electrospray ionization mass spectrometry, Biomedical Chromatography, 24, 140-147 (2010).

 

[2009]

1. M.Sakakura and M.Takayama, Sonolytic hydrolysis of peptides in aqueous solution upon addition of catechol, Ultrasonics Sonochemistry, 16, 367-371 (2009).

2. K.Sekimoto and M.Takayama, Fundamental Processes of Corona Discharge ?Surface Analysis of Traces Stained with Discharge on Brass Plate in Negative Corona-, J. Institute of Electrostatics Jpn., 33, 38-43 (2009).

 
[2008]

1. K.Sekimoto and M.Takayama, Dependence of negative ion formation on inhomogeneous electric field strength in atmospheric pressure negative corona discharge, European Physical Journal D, 50, 297-305 (2008).

2. Y.Iida, H.Ichiba, E.Saigusa, N.Sato and M.Takayama, Study of endocrine disruptor octylphenol isomers using collision-induced dissociation mass spectrometry, J. Mass Spectrom. Soc. Jpn., 56, 215-222 (2008).

3. S.Horiyama, C.Honda, K.Suwa, Y.Umemoto, Y.Okada, M.Semma, A.Ichikawa and M.Takayama, Sensitive and simple analysis of sorbic acid using liquid chromatography with electrospray ionization mass spectrometry, Chem. Pharm. Bull., 56, 578-581 (2008).

 

[2007]

1. Y.Nabuchi, N.Murao, Y.Asoh and M.Takayama, Probing the unfolding and refolding of carbonic anhydrase 2 using electrospray ionization mass spectrometry combined with pH jump, Anal. Chem., 79, 8342-8349 (2007).

2. T.Nishikaze and M.Takayama, Disappearance of interfering alkali-metal adducted peaks from MALDI mass spectra of peptides with serine addition to CHCA matrix, Rapid Commun. Mass Spectrom., 21, 3345-3351 (2007).

3. T.Nishikaze and M.Takayama, Study of factors governing negative molecular ion yields of amino acid and peptide in FAB, MALDI and ESI mass spectrometry, Int. J. Mass Spectrom., 268, 47-59 (2007).

4. K.Sekimoto and M.Takayama, Influence of needle voltage on the formation of negative core ions using atmospheric pressure corona discharge in air, Int. J. Mass Spectrom., 261, 38-44 (2007).

 

[2006]

1. M.Takayama, M.Tachibana, T.Uchida, H.Kawamoto, T.Nishikaze, S.Kawabata, T.Nishimoto, N.Fujikawa, K.Awata and K.Kojima, Evidence for the presence of fullerene in diesel soot using laser desorption/ionization mass spectrometry, J. Mass Spectrom. Soc. Jpn., 54, 39-44(2006).

2. T.Nishikaze and M.Takayama, Cooperative effect of factors governing molecular ion yields in desorption/ionization mass spectrometry, Rapid Commun. Mass Spectrom., 20, 376-382 (2006).

 

[2004]

1. Y.Nabuchi, Y.Asoh and M.Takayama, Folding Analysis of Hormonal Polypeptide Calcitonins and the Oxidized Calcitonins Using Electrospray Ionization Mass Spectrometry Combined with H/D Exchange, J. Am. Soc. Mass Spectrom., 15, 1556-1564 (2004).

2. Y.Xiang, Z.Abliz and M.Takayama, Cleavage Reactions of the Complex Ions Derived from Self-Complementary Deoxydinucleotides and Alkali-Metal Ions Using Positive Ion Electrospray Ionization with Tandem Mass Spectrometry, J. Am. Soc. Mass Spectrom., 15, 689-696 (2004).

 

[2003]

1. Y.Xiang, Z.Abliz, L.-J.Li and M.Takayama, Characteristic fragmentation behavior of deoxytetranucletides by positive ion electrospray ionization tandem mass spectrometry, Rapid Commun. Mass Spectrum., 17, 1220-1224 (2003).

2. Y.Xiang, Z.Abliz, L.-J.Li and M.Takayama, MS/MS Study of Deoxynucleotides Bound with Alkali-Metal Ions Using ESI-MS, Chin. Chem. Lett., 14, 499-502 (2003).

 

[2002]

1. M.Takayama, Susceptible Region of Myoglobins to In-source Decay using Matrix-assisted Laser Desorption/Ionization Coupled with Reflectron Time-of-Flight Mass Spectrometer, J. Mass Spectrom. Soc. Jpn., 50, 304-310 (2002).

2. H.Kataoka, S.Horiyama, M.Yamaki, H.Oku, K.Ishiguro, T.Katagi, M.Takayama, M.Semma and Y.Ito, Anti-inflammatory and Anti-allergic Activities of Hydroxylamine and Related Compounds, Biol. Pharm. Bull., 25, 1436-1441 (2002).

3. S.Horiyama, K.Suwa, M.Yamaki, H.Kataoka, T.Katagi, M.Takayama and T.Takeuchi, Solvents including oxidation of hydroxyamines, Chem. Pharm. Bull., 50, 996-1000 (2002).

4. J.Gao, A.Tsugita, M.Takayama, L.Xu, A programmable fragmentation analysis of proteins by in-source decay in MALDI-TOF mass spectrometry, Anal. Chem., 74, 1449-1457 (2002).

 

[2001]

1. M.Takayama, N-Cα bond cleavage of the peptide backbone via hydrogen abstraction, J. Am. Soc. Mass Spectrom., 12, 1044-1049 (2001).

2. M.Takayama, In-source decay characteristics of peptides in matrix-assisted laser desorption/ionization mass spectrometry, J. Am. Soc. Mass Spectrom., 12, 420-427 (2001).

 

[2000]

1. Y.Chang, Z.Abliz, L.-J.Li, Q.-C.Fang and M.Takayama, Study of fragmentation Behavior of 5/7/6-type taxoids by tandem mass spectrometry, J. Mass Spectrom., 35, 1207-1214 (2000).

2. Z.Abliz, F.Qicheng, Fang, L.Xiaoting and M.Takayama, Study on fragmentation behavior of taxoids by tandem mass spectrometry, Chinese Science Bulletin, 45, 688-698 (2000).

3. M.Takayama and Y.Hayashi, Prediction of Measurement Precision for Quantitative Mass Spectrometry with Electron Ionization Based on FUMI Theory, J. Mass Spectrom. Soc. Jpn., 48, 248-253 (2000).

4. M.Takayama and A.Tsugita, Sequence Information of Peptides and Proteins with In-source Decay in Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry, Electrophoresis, 21, 1670-1677 (2000).

5. T.Kinumi, T.Saisu, M.Takayama and H.Niwa, Matrix-assisted laser desorption ionization/time-of-flight mass spectrometry using an inorganic particle matrix for small molecule analysis, J. Mass Spectrom., 35, 417-422 (2000).

 

[1999]

1. M.Takayama, T.Matsui, T.Sakai and A.Tsugita, A C-terminal successive degradation method for peptides with dilute hydrochloric acid, J. Biomolecular Techniques, 10, 194-198 (1999).

2. S.Horiyama, K.Suwa, Y.Yamaki, H.Kataoka, T.Katagi and M.Takayama, Reductive degradation of O-acyl oximes under fast atom bombardment conditions, European Mass Spectrom., 5, 203-211 (1999).

 

[1998]

1. K.Miyazaki, R.Shen, M.Takayama, M.Kamo, T.Kawakami, and A.Tsugita, A Novel Approach to C-terminal Sequencing at Multi-sites of Proteins, Res. Commun. Biochem. Cell Mol. Biol., 2, 175-194 (1998).

2. M.Takayama and A.Tsugita, Does in-source decay occur independent of the ionization process in matrix-assisted laser desorption, Int. J. Mass Spectrom., 181, L1-L6 (1998).

3. M.Konishi, Y.Hano, M.Takayama, T.Nomura, A.S.Hamzah, R.Ahamad, and H.Jasmani, Nudicaucins A, B and C, three Triterpenoid Saponins from Hedyotis Nudicaulis, Phytochemistry, 48, 525-528 (1998).

4. A.Tsugita, M.Kamo, K.Miyazaki, M.Takayama, T.Kawakami, R.Shen, and T.Nozawa, Additional tools for identification of protein, Electrophoresis, 19, 928-938 (1998).

5. M.Takayama, A Terminal Product Ion in the Fragmentation of Methyl Stearate under Electron Ionization Conditions, J. Mass Spectrom. Soc. Jpn., 46, 139-142 (1998).

6. M.Takayama, Ionization Efficiency of Matrix Surface Bombarded with Xe, Ar and He Beams, J. Mass Spectrom. Soc. Jpn., 46, 33-36 (1998).

 

[1997]

1. M.Takayama, T.Shida, and A.Tsugita, A Novel Spectrometric Method for Determining the Ability of Intermolecular Association: Deoxymononucleotides and Deoxydinucleotides, Res. Commun. Biochem. Cell Mol. Biol., 2/3, 185-203 (1997).

 

[1996]

1. M.Takayama, K.Hiraoka, and H.Nakata, Formation of the [M+H]+ and Abundant Fragment Ions of Methyl Stearate under Low Energy Electron Ionization Conditions, J. Mass Spectrom. Soc. Jpn., 44, 531-541 (1996).

2. M.Takayama, Fast Atom Bombardment Mass Spectrometry: Ionization Mechanism, J. Mass Spectrom. Soc. Jpn., 44, 501-530 (1996).

3. M.Takayama, T.Kosaka, and T.Kinoshita, Formation of [M - H]- Ions under Fast Atom Bombardment Conditions: Trolox and α-tocopherol, J. Mass Spectrom. Soc. Jpn., 44, 473-481 (1996).

4. T.Kosaka, T.Kinoshita, and M.Takayama, Ion Formation and Fragmentation of Sinapinic Acid in Electron Ionization, Liquid Secondary Ion and Matrix-assisted Laser Desorption/Ionization Mass Spectrometry, Rapid Commun. Mass Spectrom., 10, 405-408 (1996).

5. M.Takayama, Gas-phase Fast-atom Bombardment Mass Spectrometry, Int. J. Mass Spectrom. Ion Processes, 152, 1-20 (1996).

 

[1995]

1. M.Takayama, Formation of [M-H]- Ions under Fast-atom Bombardment Conditions: Which is reflected, gas-phase or solution chemistry ?, J. Mass Spectrom. Soc. Jpn., 43, 279-291 (1995).

2. S.Horiyama, K.Suwa, M.Yamaki, H.Kataoka, T.Katagi, and M.Takayama, Thermal Degradation of O-Acyl Oximes under Electron Impact Ionization Conditions, Rapid Commun. Mass Spectrom., 9, 971-977 (1995).

3. M.Takayama, K.Hiraoka, and H.Nakata, Surface Ionization and Electron Impact-induced Fragmentation of the [M+H]+ Ions of Stearic Acid Methyl Ester, Int. J. Mass Spectrom. Ion Processes, 148, L11-L16 (1995).

4. M.Takayama, How Is The Molecular Ion of α-Tocopherol Formed under Fast-atom Bombardment Conditions ?, J. Mass Spectrom., 30, 1352-1358 (1995).

5. M.Takayama, Collision-induced Dissociation of the Alkali-metal Adduct Ions [M+c]+ and [M+2c-H]+ (c=Na and K): Trolox and a Phospholipid, J. Mass Spectrom. Soc. Jpn., 43, 177-188 (1995).

6. M.Takayama, Metastable McLafferty Rearrangement Reaction in the Electron Impact Ionization of Stearic Acid Methyl Ester, Int. J. Mass Spectrom. Ion Processes, 144, 199-204 (1995).

7. M.Takayama, T.Nomura, and K.Nojima, Structure of the Diene Originating from a retro-Diels-Alder Cleavage of the Natural Product Kuwanon G, Rapid Commun. Mass Spectrom., 9, 383-386 (1995).

8. T.Nishimura and M.Takayama, Some Characteristics of Gas-Phase Fast Atom Bombardment Ionization Mass Spectrometry: Chromium Hexacarbonyl and Trolox, J. Mass Spectrom. Soc. Jpn., 43, 85-96 (1995).

9. M.Takayama, Formation of M+. Ions and Electronic Excitation under Fast-Atom Bombardment  Conditions By Using a Liquid Matrix, J. Am. Soc. Mass Spectrom., 6, 114-119 (1995).

 

[1994]

1. M.Takayama, M.Iwamura, and S.Fuchibe, Formation of M+. Ions Produced Under Matrix Fast Atom Bombardment Conditions: Does Charge Exchange Reaction Occur ?, Org. Mass Spectrom., 29, 601-606 (1994).

2. M.Takayama, Fast Atom Bombardment Mass Spectrometry: Matrix Effects on Ion Formation and Fragmentation, J. Mass Spectrom. Soc. Jpn., 42, 249-275 (1994).

3. M.Takayama, Successive Neutral C2 Losses from Fullerenes C60 and C70 Ions using Gas-phase Fast Particle Bombardment Technique, J. Mass Spectrom. Soc. Jpn., 42, 193-206 (1994).

4. M.Takayama, Formation of Quadruply-charged Ion of C60 by Gas-phase Fast-particle Bombardment using He, Ar and iso-butane Beams, Int. J. Mass Spectrom. Ion Processes, 134, L1-L5 (1994).

5. M.Takayama, Formation and Collision-induced Dissociation of Adduct Ions [matrix+C]+ (C=Li, Na, Cs and NH4) Produced Under Fast Atom Bombardment Conditions, Int. J. Mass Spectrom. Ion Processes, 136, 35-44 (1994).

6. M.Takayama, Formation of Deprotonated Molecules [M-H]- of α-tocopherol under Fast-atom Bombardment Conditions, Rapid Commun. Mass Spectrom., 8, 309-312 (1994).

7. A.Shigihara and M.Takayama, An MO Theoretical Study on Isobutene Loss from Protonated Prenylated Flavonoids, J. Mass Spectrom. Soc. Jpn., 42, 117-122 (1994).

8. M.Takayama, Suitable Matrices for Various Compounds in Fast Atom Bombardment Mass Spectrometry, J. Mass Spectrom. Soc. Jpn., 42, 11-23 (1994).

9. M.Takayama and H.Shinohara, Ion Formation and Degradation of C70 by Gas-phase Fast-atom Bombardment with Helium Beam, Fullerene Science and Technology, 2, 165-171 (1994).

 

[1993]

1. M.Takayama, Y.Tanaka, and T.Nomura, Competitive Formation of M+. and [M + H]+ Ions under Fast-atom Bombardment Conditions, Org. Mass Spectrom., 28, 1529-1535 (1993).

2. M.Takayama, Collision-induced Dissociation of Glycoside-Alkali Metal Adduct Ions in Fast Atom Bombardment Mass Spectrometry, Org. Mass Spectrom., 28, 878-882 (1993).

3. M.Takayama, Y.Tanaka, and T.Nomura, Influence of Acetylation on the [M + Na]+ Ion Formation of Simple Phenol and Aniline Compounds under Fast-atom Bombardment Conditions, Rapid Commun. Mass Spectrom., 7, 172-175 (1993).

4. M.Takayama, Ion Formation and Fragmentation in Gas-phase Fast-atom Bombardment Mass Spectrometry of C60, Fullerene Science and Technology, 1, 411-424 (1993).

5. M.Takayama and H.Shinohara, Ionization and Fragmentation of C60 by Gas-phase Fast-atom Bombardment Using He, Ar and Xe Beams, Int. J. Mass Spectrom. Ion Processes, 123, R7-R11 (1993).

6. M.Takayama, and H.Shinohara, Production and Degradation of Multiply Charged C60 Ions, Org. Mass Spectrom., 28, 61-62 (1993).

 

[1992]

1. M.Takayama, Gas-phase Fast Atom Bombardment Mass Spectra of Fullerenes and Pyrene, Int. J. Mass Spectrom. Ion Processes, 121, R19-R25 (1992).

2. M.Takayama, T.Fukai, Y.Hano, and T.Nomura, Mass Spectrometry of Prenylated Flavonoids, Heterocycles, 33, 405-434 (1992).

 

[1991]

1. M.Takayama, 1,5-Pentanediol as a Matrix for Negative-ion Fast Atom Bombardment Mass Spectrometry, Org. Mass Spectrom., 26, 1123-1124 (1991).

2. M.Takayama and T.Nomura, Molecular Ion M+. Formation under Fast-atom Bombardment Conditions Using Protic and Aprotic Liquid Matrices, Mass Spectroscopy, 39, 345-350 (1991).

3. H.Shinohara, H.Sato, Y.Saito, M.Takayama, A.Izuoka, and T.Sugawara, Formation and Extraction of Very Large All-Carbon Fullerenes, J. Phys. Chem., 95, 8449-8451 (1991).

4. M.Takayama, T.Nomura, T.Yokoyama, K.Nojima, and T.Minowa, Fast atom Bombardment-induced Fluorescence, Int. J. Mass Spectrom. Ion Processes, 108, R21-R25 (1991).

5. M.Takayama, T.Fukai, T.Nomura, and T.Yamauchi, Formation and Fragmentation of the [M + Na]+ Ion of Glycosides in Fast Atom Bombardment Mass Spectrometry, Org. Mass Spectrom., 26, 655-659 (1991).

6. M.Takayama, T.Nomura, and M.Konishi, Direct Evidence for Degradation of Esperamicin A1 with Thiol Confirmed by Fast-atom Bombardment Mass Spectrometry, Rapid Commun. Mass Spectrom., 5, 252-254 (1991).

7. M.Takayama, T.Fukai, K.Ichikawa, and T.Nomura, Identification of Prenylated Flavonoids Using Fast-atom Bombardment Mass Spectrometry, Rapid Commun. Mass Spectrom., 5, 67-69 (1991).

 

[1990]

1. M.Takayama and T.Nomura, Molecular Ion M+. Formation in Fast Atom Bombardment Mass Spectrometry (FAB-MS), Spectros. Int. J., 8, 245-260 (1990).

2. T.Fukai, Q.-H.Wang, M.Takayama, and T.Nomura, Structures of Five New Prenylated Flavonoids, Gancaonins L, M, N, O, and P from Aerial Parts of Glycyrrhiza Uralensis, Heterocycles, 31, 373-382 (1990).

3. M.Takayama, T.Fukai, Y.Hano, and T.Nomura,  A New Matrix System in Fast Atom Bombardment Mass Spectrometry of Prenylated- and Geranylated-Phenolic Compounds, Mass Spectroscopy, 38, 77-85 (1990).

4. M.Takayama, T.Fukai, T.Nomura, and K.Nojima, Further Study of The Matrix Effect on The Extent of Fragmentation in Molecular Ions M+. Produced Under Fast Atom Bombardment (FAB) Conditions, Int. J. Mass Spectrom. Ion Processes, 96, 169-179 (1990).

 

[1989]

1. M.Takayama, T.Fukai, T.Nomura, and K.Nojima, Tandem Mass Spectrometric Study on Fragmentation in Fast Atom Bombardment Mass Spectra of Prenylated Flavonoids, Mass Spectroscopy, 37, 239-247 (1989).

2. M.Takayama, T.Fukai, and T.Nomura, Matrix Effect on The Extent of Fragmentation in Molecular Ion M+. Produced Under Fast Atom Bombardment (FAB) Conditions, Int. J. Mass Spectrom. Ion Processes, 89, R1-R5 (1989).

3. M.Takayama, T.Fukai, T.Nomura, and K.Nojima, Direct Evidence of Both Electron Ionization- and Chemical Ionization-like Fragmentation in Fast-atom Bombardment Mass Spectra of Prenylated Flavonoids Confirmed by Tandem Mass Spectrometry, Rapid Commun. Mass Spectrom., 3, 4-6 (1989).

4. M.Takayama, T.Fukai, and T.Nomura, Studies on Fast Atom Bombardment (FAB), Electron Ionization (EI) and Chemical Ionization (CI) Mass Spectra of Prenylated Flavonoids, Mass Spectroscopy, 37, 129-140 (1989).

 

U.査読付日本語原著論文

1. 関本奏子、高山光男:大気中コロナ放電によるイオンの生成と発展の研究,エアロゾル研究,26, 203-213 (2011).

2. 石井啓介・浅原麻希子・高山光男Study of cuticular chemicals of Formica japonica Ant using gas chromatography/mass spectrometry ?Temporal modulation in the pattern of cuticular hydrocarbons-, J. Mass Spectrom. Soc. Jpn., 57, 61-70 (2009).

3. 高山光男、片岡裕美、加多木豊行之、堀山志朱代、山木正枝、長谷川富喜子、Z.Abliz:高速原子衝撃質量分析法における新しいマトリックス, J. Mass Spectrom. Soc. Jpn., 46, 143-149 (1998).

4. 高山光男、高橋利枝:高速原子衝撃質量分析法におけるマトリックスの選択基準, J. Mass Spectrom. Soc. Jpn., 44, 493-497 (1996).

5. 高山光男、深井俊夫、野村太郎:FABMSにおける低極性有機化合物のための新しいマトリックス系の効果、Mass Spectroscopy, 36, 169-173 (1988).

6. 高山光男、深井俊夫、野村太郎:チオグリセロールをマトリックスとしたプレニルフラボノイド類のFABマススペクトロメトリー、Mass Spectroscopy, 35, 210-214 (1987).

 

V.その他 論文

1. M.Takayama, Unusual fragmentation of peptide and protein in matrix-assisted laser desorption/ionization mass spectrometry, J. Instr. Anal. China, 20, 12-13 (2001).

2. X.Yun, Z.Abliz, L.-J.Li and M.Takayama, Characteristic fragmentation of deoxytetranucleotides by electrospray tandem mass spectrometry, J. Instr. Anal. China (in Chinese), 20, 37-38 (2001).

3. Z.Abliz, Y.Chang, Q.-C.Fang and M.Takayama, Study of fragmentation of 5/7/6 type taxoid by tandem mass spectrometry, J. Chin. Mass Spectrom. Soc., 20, 173-174 (1999).

4. Z.Abliz and M.Takayama, Structural Analysis of Condensed Polycyclic Aromatic Compounds by Tandem Mass Spectrometry, Chem. J. Chin. Univ., 17, 1356 (1996).

8. 高山光男、均質液体の過熱破壊機構について、物性研究, 39, 1 (1982).

 

W.著書(共著・分担)・編著

1.     高山光男 他編:“現代質量分析学”,化学同人,京都(2013).

2.     高山光男:“臨床プロテオミクス”,加藤治文監修,金原出版,東京(2012pp.125-129

3. 高山光男:“翻訳後修飾のプロテオミクス”,平野久・大野茂男編,講談社,東京(2011pp.8-26

4. 高山光男:“改訂六版 分析化学便覧”,日本分析化学会編,丸善,東京(2011pp.762-764

5. 高山光男:“タンパク質入門”,内田老鶴圃,東京2006.

6. 高山光男:“タンパク質研究なるほどQ&A”,戸田 他編,洋土社,東京(2005).

7. 高山光男:“ゲノミクス・プロテオミクスの新展開”,加藤郁之進 他編,エヌ・チィー・エス,東京(2004pp.475-479.

8. 高山光男:“ポストゲノム・マススペクトロメトリー”化学フロンティアI,丹羽利充編,化学同人,京都 (2003) pp.59-72.

9. 高山光男:“プロテオミクス”現代化学増刊42,鈴木紘一監修,東京化学同人,東京 (2002) pp.10-14.

10. M.Takayama and A.Tsugita: Mass Spectrometry in Protein Study, in “New Advances in Analytical Chemistry”, Atta-ur-Rahman ed., Taylor & Francis, London (2002) pp.163-209.

11. 明石知子・高山光男・豊田岐聡・橋本豊・平岡賢三・平山和雄 共著:"マススペクトロメトリーってなあに",国際文献印刷社,東京 (2001).

12. 志田保夫・笠間健嗣・黒野定・高山光男・高橋利枝共著:“これならわかるマススペクトロメトリー”,化学同人,京都 (2001).

13. M.Takayama: The analysis of structure and function of organic compounds using fast atom bombardment mass spectrometry, in "New Advances in Analytical Chemistry", Atta-ur-Rahman ed., Gordon and Breach Science Publishers, Amsterdam (2000) pp.31-76.

14. 奥野和彦・高山光男・中田尚男・平岡賢三 編:"マススペクトロメトリー関係用語集",国際文献印刷社,東京 (1998).

15. 高山光男:イオン化法,"バイオロジカルマススペクトロメトリー",上野民夫・平山和雄・原田健一編:現代化学・増刊31,東京化学同人,東京 (1997) pp.3-15.

16. 羽野芳夫・加藤太郎・田中克明・高山光男・野村太郎:FAB-MS スペクトルを用いた抗酸化物質のスクリーニング法,“ビタミンE研究の進歩”V巻,共立出版,東京 (1995) pp.93-98.

 

X.総説・解説

[2009]

1. 高山光男:質量分析装置のためのイオン化法 総論,ぶんせき,1, 2-7(2009).

[2008]

1. 田中耕一・吉野健一・絹見朋也・高山光男:なぜリフレクトロンモードでMS/MS様の測定が可能なのか,J. Mass Spectrom. Soc. Jpn., 56, 263-268 (2008).

[2006]

1. 高山光男:BMSにおけるイオン化法の発展,

[2005]

1. 西風隆司・高山光男:有機化合物のイオン化法,化学工業,56, 606-611 (2005).

2. 高山光男:ナノ構造の新しい展開 バイオ研究への展開,機械の研究,57, 168-174 (2005).

[2004]

1. 高山光男:マトリックス支援レーザー脱離イオン化法,真空,47, 618-626 (2004).

2. 高山光男:質量分析の進歩と化学・生物学へのインパクト,化学と工業,57, 229-231 (2004).

[2003]

1. 高山光男:ノーベル賞受賞に導いた魔法のマトリックスとは,蛋白質 核酸 酵素,48, 63-66 (2003).

2. 高山光男:マトリックス支援レーザー脱離イオン化法を使うタンパク質の構造研究,レーザー研究,31, 9-12 (2003).

3. 高山光男:有機化合物のイオン化法,ぶんせき,4, 170-175 (2003).

4. 高山光男:MALDIと結合した分析装置と応用分野,日本医事新報,4122, 102-103 (2003).

[2002]

1. 高山光男:各種質量分析分解法におけるインソース分解の特徴 ?Hydrogen-attachment Dissociation (HAD)-,質量分析,50, 337-349 (2002).

[2000]

1. 次田晧・高山光男:プロテオーム解析に使われるタンパク質の分離同定法の概要,細胞工学,19, 1234-1240 (2000).

2. 高山光男:プロテオミクスを支えるプロテインマススペクトロメトリー,質量分析,48, 193-197 (2000).

[1999]

1. 高山光男:マススペクトロメトリー初歩の初歩,質量分析,47, 211-228 (1999).

[1997]

1. 高山光男:分子にやさしい最新のイオン化法,ファルマシア, 33, 1001-1003 (1997).

2. 高山光男:続々ファインスペクトルを得るために -デバイスからイオン化法の選択をながめると-,質量分析, 45, 219-224 (1997).

3. 高山光男:続ファインスペクトルを得るために -デバイスからイオン化法の選択をながめると-,質量分析, 45, 91-99 (1997).

[1996]

1. 高山光男・石川啓一郎:マッシブクラスター衝撃イオン化法 (MCI) -生体高分子への可能性-,質量分析, 44, 97-102 (1996).

2. 高山光男:ファインスペクトルを得るために -デバイスからイオン化法の選択をながめると-,質量分析, 44, 653-656 (1996).

3. 高山光男:イオン化技術と有機質量分析,ぶんせき, 4, 270-276 (1996).

[1993]

1. 高山光男:C60 の反応性 -生理活性フラーレンは可能か,ファルマシア, 29, 890 (1993).

[1992]

1. 高山光男:タンデム質量分析法によるペプチド研究の新領域,ファルマシア, 28, 1254 (1992).

 

Y.特 許 (申請中含む)

1.    高山光男(発明者):高速原子衝撃質量分析法における新規マトリックス剤 Super FABMS、東京化成工業(株)申請、特開平9-113485.

2.    高山光男(発明者):超音波によるペプチドの分解反応とアミノ酸配列解析 (2008).

3.    高山光男・坂倉幹始(発明者):ペプチド主鎖のN-Ca結合の特異的切断方法 (2010).

4.    高山光男・大坂一生(発明者):タンパク質とリン酸化ペプチド主鎖のN-Ca結合またはCa-C結合の特異的切断方法 (2011).

5.    高山光男・関本奏子(発明者):大気圧コロナ放電イオン化システム及びイオン化方法 (2011).

6.    田中耕一・岩本慎一・関谷禎規・高山光男(発明者):質量分析方法及び質量分析データ処理装置(2013).

7.    関本奏子・高山光男(発明者):大気圧コロナ放電システムを用いたアンビエントイオン化質量分析法の高感度化技術(2013).